2 articles
Osteocalcin, a bone-derived hormone, has emerged as a potential regulator of energy metabolism, with roles in insulin sensitivity, glucose homeostasis, and lipid metabolism. Although an inverse association between osteocalcin and body mass index has been previously reported, data on its link with metabolic parameters in young, otherwise healthy women with obesity remain limited. The objective of this study was to investigate the relationship between circulating osteocalcin levels and key metabolic parameters in this specific population.
A cross-sectional observational study was conducted among 85 Caucasian women aged 18-45 years, without chronic disease or medication use. Participants were classified into two groups: normal weight (BMI 18.5-24.9 kg/m², n = 47) and with obesity (BMI ≥ 30 kg/m², n = 38). Anthropometric, hemodynamic, and biochemical parameters, including glucose, insulin, lipid profile, osteocalcin, and adiponectin, were assessed. Insulin resistance was evaluated using HOMA-IR and QUICKI. Group comparisons and Pearson correlation analyses were performed.
Osteocalcin levels were significantly lower in the group of women with obesity compared to the normal weight group (12.99 ± 4.7 vs. 19.75 ± 4.09 ng/mL, p < 0.001). It was inversely correlated with BMI (r = – 0.56), waist-to-hip ratio, waist-to-height ratio, insulin, HOMA-IR, total and LDL cholesterol, and positively associated with QUICKI (r = 0.39) and adiponectin (r = 0.31) (all p < 0.001). A progressive decline in osteocalcin levels was observed across obesity grades.
Circulating osteocalcin is inversely associated with adiposity and metabolic dysfunction, suggesting its potential as an early biomarker of cardiometabolic risk in young women with obesity.
Obesity is a metabolic disease that presents a real challenge for the medical system due to the significant increase in the number of obese people in recent decades. Currently, 38% of the global population is overweight or obese. Obesity is an important risk factor for multiple chronic pathologies and lung infections, especially pneumonia. For obese subjects, chronic proinflammatory status due to an excess of fat cells is characteristic.
This prospective cohort study is based on clinical and laboratory examinations of patients hospitalized with community-acquired pneumonia in the Department of Internal Medicine at „Holy Trinity” Municipal Hospital, Chisinau, Republic of Moldova. The study included 210 patients with community-acquired pneumonia, divided into two groups: the base group (group 1) consisted of 105 patients with varying degrees of obesity, and the control group (group 2) consisted of 105 normal-weight patients. The research was conducted according to the principles of the Helsinki Declaration - WMA Declaration of Helsinki - Ethical Principles for Medical Research Involving Human Subjects. The study was approved by the Research Ethics Committee of the Nicolae Testemiţanu State University of Medicine and Pharmacy, with the issuance of favorable opinion no. 46 from March 27, 2018. All patients were examined clinically and paraclinically (radiological examination, pulse oximetry screening, complete blood count, erythrocyte sedimentation rate, fibrinogen, LDH, C-reactive protein, oxidative stress markers). The obtained data were statistically analyzed using Statistical Package for the Social Sciences (SPSS) version 20.
According to the obtained data, the most common comorbidities associated with obesity were cardiovascular and metabolic diseases. The main symptom that prevailed in the obese was dyspnea (97%). Obese subjects showed more frequent signs of acute respiratory failure (86.7%), required oxygen therapy with an average duration of 7.62±6.23 days, showed increased serum levels of LDH (286.31±94.66 U/L) and C-reactive protein (66.08±71.44 mg/l), data that influenced the clinical course of pneumonia.
Patients with obesity and community-acquired pneumonia presented with infectious symptoms and acute respiratory failure, increased values of inflammatory markers, and required oxygen therapy more frequently compared to those of normal weight.