Hemophilia is a genetic disorder characterized by impaired blood coagulation, leading to increased bleeding risk. The severity of hemophilia varies significantly among individuals, influenced by genetic factors, family inheritance patterns, and the occurrence of complications such as hemarthrosis. Understanding these interrelationships is crucial for developing tailored management strategies for affected children. The purpose of this article is to explore the correlations between clinical severity and various factors, including modes of inheritance, hemarthrosis incidence, types of genetic mutations, and inhibitor presence in pediatric patients with hemophilia. By elucidating these relationships, the study aims to contribute to improved diagnostic and therapeutic approaches in this population.

Axial spondylitis is a chronic inflammatory disease primarily affecting the axial skeleton but can also involve peripheral joints. Axial spondylitis is often associated with extra-articular manifestations, such as inflammatory bowel diseases, emphasizing the need for rigorous monitoring and personalized therapeutic approaches. The interactions between axial spondylitis and inflammatory bowel diseases fall under the concept of “immune-mediated inflammatory diseases”, sharing common pathogenetic mechanisms. This study analyzes the prevalence and characteristics of inflammatory bowel diseases in patients with axial spondylitis

Despite worldwide decreasing trends in the incidence of gastric cancer, the disease remains a significant global health burden, one of the leading causes of cancer death worldwide, and its prevention is a priority for the health system. Intestinal-type gastric carcinoma originates in dysplastic epithelium, which, in turn, develops in the environment of chronic atrophic gastritis and gastric intestinal metaplasia.

Currently, extensive research has shown that almost all published prediction models are poorly studied and have significant limitations, leading to their predictive performance often being overestimated. Additionally, there is still no universally accepted scoring system, primarily due to the need for adaptation to heterogeneous patient samples (including patient numbers, clinical profiles, and risk factors) and/or ongoing differences in the organization of healthcare systems across various countries.

Immediate loading of dental implants is an evolving discipline requiring validation through clinical and statistical analyses. This study presents a case of immediate implantation and loading to evaluate predictability and outcomes. Immediate restoration reduces treatment time, promotes rapid aesthetic recovery, and addresses patient expectations for functional rehabilitation. Success in such cases relies heavily on maintaining primary stability and avoiding micromovements during osseointegration