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COVID-19 as a possible risk factor for poor prognosis in systemic sclerosis
Svetlana Agachi*, Serghei Popa, Larisa Rotaru, Eugeniu Russu, Lucia Dutca, Irina Meleșco, Valeria Stog
https://doi.org/10.52645/MJHS.2025.2.10
Scleroderma Renal Crisis (SRC) is a life-threatening complication of systemic sclerosis (SSc), traditionally associated with anti-RNA polymerase III antibodies, corticosteroid use, and diffuse skin involvement. However, the role of COVID-19 as a potential trigger for SRC remains poorly understood. This study explores the occurrence of COVID-19-associated SRC, focusing on its clinical presentation, underlying risk factors, and outcomes
Chronic kidney disease – a major public health problem
Costina Groza*, Liliana Groppa, Larisa Rotaru, Tatiana Razlog, Dorian Sasu, Serghei Popa
https://doi.org/10.52645/MJHS.2025.2.09
Chronic kidney disease (CKD) is a major and growing global public health problem, contributing to significant morbidity, mortality, and financial strain on healthcare systems. Despite available preventive measures, CKD often remains underdiagnosed and insufficiently addressed by health policies worldwide.
The role of autoantibodies in neuropsychiatric systemic lupus erythematosus: mechanisms, biomarkers and clinical correlations
Eugeniu Russu1,2, Liliana Groppa1, Lia Chișlari1, Marius Semionov1, Iosif Leanca1, Artemie Pastuhov1, Chiril Nartea1
https://doi.org/10.52645/MJHS.2025.2.08
Neuropsychiatric lupus erythematosus is still a disease with a very challenging diagnostic process, lacking high specificity and sensitivity assays. Autoantibodies can change this perspective, and because of their pathogenetic involvement, can become a very powerful tool for early detection and disease activity tracking. However, their biomarker potential still needs further evaluation. In this study, we focused on the pathogenetic mechanisms of neuropsychiatric lupus erythematosus and the involvement of brain-specific and systemic autoantibodies in the development of neuropsychiatric manifestations.
Assessment of osteoarticular morbidity in regions with different boron concentrations in deep drinking water of the Republic of Moldova
Maria-Victoria Racu*1, Iurie Pînzaru1, Elena Ciobanu2, Lucia Mazur-Nicorici3
https://doi.org/10.52645/MJHS.2025.2.07
Even if boron is not yet recognized as an essential element for the human body, its insufficient intake is considered harmful, especially for the osteoarticular system. A daily intake of at least 3 mg of boron can fortify bone mass and prevent the onset of osteoarthritis, rheumatoid arthritis, and osteoporosis. This research aims to assess the morbidity caused by rheumatoid arthritis and inflammatory polyarthropathies in the population from regions with different boron concentrations in deep drinking water of the Republic of Moldova.
Interdental contact – morphofunctional component of the stomatognathic system
Victoria Ababii*, Diana Marcu, Sergiu Ciobanu
https://doi.org/10.52645/MJHS.2025.2.05
As part of the interproximal assembly, the interdental contact is a morphofunctional component that contributes to the stabilization of teeth, maintaining the integrity of the dental arch, protecting the papilla, and preventing food impaction. The aim of the study is to radiologically evaluate the proximal morphology of restored surfaces on lateral teeth and the positioning of the interdental contact
Exploring knowledge and perceptions of domestic violence among medical students and physicians in the Republic of Moldova
Petru Glavan*, Andrei Pădure, Anatolii Bondarev
https://doi.org/10.52645/MJHS.2025.2.04
Domestic violence is one of the most widespread human rights violations in the world. The health sector plays a vital role in preventing domestic violence, helping to identify abuse early, providing victims with the necessary treatment, and referring them to appropriate care. The paper aims to explore the level of knowledge and perceptions in the field of domestic violence among current and future physicians in the Republic of Moldova, in order to assess their educational needs
Development of a mathematical model for thrombosis risk prediction using serum biomarkers
Dan Croitoru1, Iurie Trohin1, Ecaterina Pavlovschi2, Oleg Arnaut3, Eugen Cerevan4
https://doi.org/10.52645/MJHS.2025.2.03
Thrombosis is a frequently underdiagnosed condition associated with high mortality in neglected cases. Many factors, including geoheliophysical and biochemical ones, are responsible for thrombosis modulation. Routine investigations may sometimes be inconsistent and, thus, unreliable in a clinical setting.