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Advances in disease-modifying therapies for multiple sclerosis: global updates and a regional comparison between the Republic of Moldova and Romania
Anna Belenciuc1,2*, Olesea Odainic2, Marina Sangheli1, Elena Manole1, Carmen Adella Sîrbu3,4,5, Vitalie Lisnic1
https://doi.org/10.52645/MJHS.2026.1.15
The therapeutic landscape of multiple sclerosis has undergone a remarkable transformation over the past two decades. The paradigm has shifted from reliance on moderate-efficacy, first-generation injectable therapies toward earlier adoption of high-efficacy disease-modifying treatments, particularly in relapsing forms of MS. This evolution reflects an increasing focus on early intensive treatment strategies aimed at preserving long-term neurological function and brain health.
Obstetrical anesthesia for a patient with multiple sclerosis: case report and literature review
Svetlana Plămădeală1,2, Dmitri Coloman2, Roman Ciubara1,2, Natalia Belîi1,2,3*
https://doi.org/10.52645/MJHS.2024.1.10
The article focuses on the management of anesthesia in obstetric patients with multiple sclerosis (MS). It presents a case study of a 25-year-old pregnant woman with relapsing-remitting MS and epilepsy, who required an urgent cesarean delivery. The study discusses the choice between general and neuraxial anesthesia, emphasizing the potential risks associated with each. Neuraxial epidural anesthesia was used successfully, and the patient's condition was monitored for one year postpartum. The article highlights the lack of extensive studies on anesthetic techniques for pregnant women with MS and suggests that using epidural anesthesia at the minimum effective concentration can reduce risks.