Chronic limb-threatening ischemia represents the advanced stage of atherosclerosis and is often associated with significant cardiovascular morbidity, resulting in high mortality rates. The hybrid approach combines surgical and endovascular techniques, allowing for optimal revascularization of multilevel lower limb atherosclerotic lesions. Additionally, the hybrid approach offers the advantages of shorter procedure times and reduced trauma compared to the classical method. It is also expected to result in a shorter length of hospital stay for patients. Therefore, the aim of this study is to analyze the relationship between the hybrid approach and the length of hospital stay compared to the classical vascular surgical approach in patients with chronic limb-threatening ischemia, multilevel atherosclerosis, and a high anesthesiologic risk.