The irrational use of antibiotics is one of the main factors contributing to the accelerated development of antimicrobial resistance worldwide. Despite the regulations established to control the procurement of antimicrobial drugs, the rate of self-prescribing and self-treatment with antimicrobials remains very high in most countries. To plan further measures to combat this resistance, a thorough understanding of the current reasons behind this behavior is required. The aim of the study is to explore the general public's knowledge, attitudes, and behavior regarding antibiotic consumption.
Globally, colorectal cancer (CRC) has become one of the top three causes of death from neoplasms. CRC represents a heterogeneous group of tumors, manifested both by clinical signs and the pathogenesis of its development. Most colorectal carcinomas develop from preexisting adenomas. The aim of this article is to assess the histopathological aspects and variants of primary colon neoformations in correlation with their location and morphological characteristics
The superficial circumflex iliac artery (SCIA) is a branch that originates either from the external iliac artery (EIA), or common femoral artery (CFA). Its anatomic variability is particularly relevant in plastic surgery, general surgery, and traumatology/orthopedics
Psoriatic arthritis (PsA) is a complex autoimmune disease with genetic and immunological components influencing its pathogenesis. HLA antigens are critical in determining genetic predisposition and clinical variability. This study aims to explore HLA antigen diversity in PsA patients and its relationship to clinical variants.
Axial spondylitis is a chronic inflammatory disease primarily affecting the axial skeleton but can also involve peripheral joints. Axial spondylitis is often associated with extra-articular manifestations, such as inflammatory bowel diseases, emphasizing the need for rigorous monitoring and personalized therapeutic approaches. The interactions between axial spondylitis and inflammatory bowel diseases fall under the concept of “immune-mediated inflammatory diseases”, sharing common pathogenetic mechanisms. This study analyzes the prevalence and characteristics of inflammatory bowel diseases in patients with axial spondylitis
Hemophilia is a genetic disorder characterized by impaired blood coagulation, leading to increased bleeding risk. The severity of hemophilia varies significantly among individuals, influenced by genetic factors, family inheritance patterns, and the occurrence of complications such as hemarthrosis. Understanding these interrelationships is crucial for developing tailored management strategies for affected children. The purpose of this article is to explore the correlations between clinical severity and various factors, including modes of inheritance, hemarthrosis incidence, types of genetic mutations, and inhibitor presence in pediatric patients with hemophilia. By elucidating these relationships, the study aims to contribute to improved diagnostic and therapeutic approaches in this population.
MALT lymphoma is the most common type of extranodal non-Hodgkin lymphoma. In two-thirds of cases, it originates in the stomach and is strongly associated with Helicobacter pylori infection. It presents a complex clinical picture, that can resemble multiple conditions, and typically follows a benign course
Hepatic amyloidosis is characterized by the deposition of fibrillar amyloid proteins, which result from light chain amyloidosis (AL) immunoglobulin fragments, in the extracellular space and the vessel walls of the liver. A case of primary hepatic amyloidosis without evidence of a primary or secondary cause of amyloid deposition is rare. This case was unique to the Republic of Moldova, presenting a diagnostic and therapeutic challenge for clinicians. Because the liver is rarely affected, this pathology remains underdiagnosed and is associated with a reserved prognosis.
Elevated or imbalanced levels of markers of oxidative stress and inflammation are often observed in various somatic pathologies and mental disorders, including schizophrenia
The objective of this study was to conduct a bibliographic analysis of current data regarding the impact of parasitic infestations on immune status and the progression of osteoarticular diseases within the context of parasitic infections