Fatty liver disease (FLD) is composed of a wide spectrum including metabolic associated fatty liver disease (MAFLD). Cardiovascular disease (CVD) is the leading cause of mortality in this populational group. Many risk estimation systems are in existence for improving the management of population groups, but currently, none of the available risk prediction models are authenticated in patients with hepatic steatosis.
Inborn errors of metabolism (IEM) make up a large group of disorders caused by an inherited defect of proteins that have enzymatic, carrier, receptor or structural roles. The cumulative prevalence of IEM in different populations is around 1:500 – 800 newborns, despite the fact that some of these disorders are extremely rare when taken individually. Early recognition and intervention are essential to avoiding disastrous consequences associated with IEM. The phenotype of IEM patients is very heterogeneous and only in combination with specialized metabolic test it can lead to a correct diagnosis. The aim of the study was defined as evaluation of importance of plasma amino acid profile in the diagnosis of IEM.
COVID-19 is currently considered a systemic disease affecting the immune system, primarily, lungs, heart, central nervous system, kidneys, intestines, liver and spleen. Impaired liver function and the presence of biochemical changes in liver can be found in approximately 14-53% of adults infected with SARS-CoV-2. Impaired liver function in patients infected with COVID-19 may occur due to a direct effect of the virus on hepatocytes, as well as being secondary to factors such as a systemic inflammatory response of the infected host, the onset of hypoxia (associated with lung damage), multiple organ failure, or due to abusive treatment using overlapping and hepatotoxic drugs.
A lot of research and studies are currently being carried out in the field of elaboration and optimization of topical pharmaceutical forms used in the treatment of various types of acne. Acne vulgaris is a disease with a complex etiopathogenesis with potential negative psychosocial effects on the quality of life of patients, and its prevention is based on the successful management of risk factors. There are currently many topical and systemic treatment options available, so the choice of therapy depends on the form and severity of the condition. The advantage of topical pharmaceutical forms is the ability to target early stages of acne lesions.
Due to the heterogeneous nature of systemic sclerosis, it is difficult to predict disease progression and complications. Despite the discovery of novel autoantibodies associated with systemic sclerosis (SSc), there is an unmet need for biomarkers for diagnosis, disease progression, and response to treatment
Mandibular prognathism is a facial disharmony characterized by an anterior relationship of the mandible to the upper jaw. Some authors associate the increased volume of the tongue with the development of this anomaly. Currently in scientific literature it is debated whether the tongue actively shapes the surrounding tissues or adapts to existing conditions. The aim of this study is to evaluate the volume of the tongue at the patients with class III malocclusion compared to class I patients using three-dimensional volumetric analysis based on computed tomography
Surface electromyography has proven to be a useful instrument for the assessment of success rate for different dental treatments. However, due to numerous variables that may influence the data like age, gender, fat tissue thickness etc. it is necessary to adjust the obtained values to a reference group with the same parameters.
Despite numerous fundamental clinical studies on the frequency, pathogenesis, clinical features of spondyloarthritis (SpA) in intestinal infectious diseases (IID) and intestinal damage in SpA, there are currently a number of unresolved problems, one of which is the problem of early diagnosis of arthropathies, especially associated with IID, which makes it necessary to continue the research in the scientific problem.
Study of clinical manifestations in psoriatic arthritis: enthesitis, dactylitis, peripheral arthritis, axial arthritis, skin manifestations, for early diagnosis, which would allow the establishment of an adjusted treatment and the elaboration of measures to prevent complications.
The COVID-19 pandemic has a major negative impact on health and socio-economic well-being. Understanding the characteristics of COVID-19 disease and identifying the wide range of factors affecting health and quality of life can be the key to providing viable solutions to improve the management of patients and their physical and psycho-emotional rehabilitation. The purpose of the present study was to evaluate the influence of SARS CoV-2 infection on the health status of adults hospitalized with the diagnosis of COVID-19 in the Republic of Moldova.