Globally, colorectal cancer (CRC) has become one of the top three causes of death from neoplasms. CRC represents a heterogeneous group of tumors, manifested both by clinical signs and the pathogenesis of its development. Most colorectal carcinomas develop from preexisting adenomas. The aim of this article is to assess the histopathological aspects and variants of primary colon neoformations in correlation with their location and morphological characteristics
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The superficial circumflex iliac artery (SCIA) is a branch that originates either from the external iliac artery (EIA), or common femoral artery (CFA). Its anatomic variability is particularly relevant in plastic surgery, general surgery, and traumatology/orthopedics
Psoriatic arthritis (PsA) is a complex autoimmune disease with genetic and immunological components influencing its pathogenesis. HLA antigens are critical in determining genetic predisposition and clinical variability. This study aims to explore HLA antigen diversity in PsA patients and its relationship to clinical variants.
Axial spondylitis is a chronic inflammatory disease primarily affecting the axial skeleton but can also involve peripheral joints. Axial spondylitis is often associated with extra-articular manifestations, such as inflammatory bowel diseases, emphasizing the need for rigorous monitoring and personalized therapeutic approaches. The interactions between axial spondylitis and inflammatory bowel diseases fall under the concept of “immune-mediated inflammatory diseases”, sharing common pathogenetic mechanisms. This study analyzes the prevalence and characteristics of inflammatory bowel diseases in patients with axial spondylitis
Hemophilia is a genetic disorder characterized by impaired blood coagulation, leading to increased bleeding risk. The severity of hemophilia varies significantly among individuals, influenced by genetic factors, family inheritance patterns, and the occurrence of complications such as hemarthrosis. Understanding these interrelationships is crucial for developing tailored management strategies for affected children. The purpose of this article is to explore the correlations between clinical severity and various factors, including modes of inheritance, hemarthrosis incidence, types of genetic mutations, and inhibitor presence in pediatric patients with hemophilia. By elucidating these relationships, the study aims to contribute to improved diagnostic and therapeutic approaches in this population.
Spironolactone (Spir) is a selective and competitive antagonist of aldosterone that increases the excretion of water and sodium while decreasing the excretion of potassium (K+ sparing diuretic). The substance was studied to develop qualitative and quantitative methods of analysis and to validate them according to documents regulating the quality of active pharmaceutical ingredients in the development of pharmaceutical forms
Guided bone regeneration (GBR) is a surgical method that allows the formation of new bone in areas of atrophy of the maxillary bone. The integration of the graft or the augmented bone under the mucosal flap and the primary healing of the soft tissues are essential conditions for preventing the exposure of the regeneration site and infectious complications that inevitably lead to the failure of the GBR procedure
Disability-adjusted life years (DALY) is a multidimensional measure used to quantify specific tasks of the disease. Chronic liver disease attributed to hepatitis Delta virus (HDV) is one of the major causes that contribute to morbidity and mortality in our country. The DALY estimate in HDV-induced liver disease has the potential to highlight both fatal and nonfatal outcomes of the disease and thus, help in policy making and allocation of health resources
Osteoporosis remains a major public health issue, particularly affecting the elderly, and is characterized by decreased bone mass and deterioration of bone structure, increasing the risk of severe fractures. The development of specific and precise tools that allow for the identification and estimation of the influence of modifiable factors on the development of osteoporosis is an important step in early intervention for at-risk individuals
Umbilical cord pathology can contribute to neonatal asphyxia, stillbirth, and postnatal death in numerous cases. However, the diagnosis of umbilical cord pathology remains imperfect, and its impact on pregnancy course and outcome is often underestimated. Therefore, prenatal diagnosis of umbilical cord pathology is becoming increasingly important in preventing intra- and postnatal morbidity and mortality. Early detection of these abnormalities enables the development of necessary strategies for optimal pregnancy and delivery management