Metabolic risk factors for non-communicable chronic diseases develop from an early age, while the clinical manifestations of cardiovascular diseases associated with these risk factors appear later in life. Dyslipidemia is a modifiable risk factor for cardiovascular diseases. The purpose of the study was to evaluate the lipid profile in young people as an early risk factor for cardiovascular disease.
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Refractory heart failure with a poor prognosis is a key feature of dilated cardiomyopathy. Inflammatory cardiomyopathy, often diagnosed via in vivo subendomyocardial biopsy, is considered a potential precursor to dilated cardiomyopathy. The Dallas criteria, applied to morphometric and electron microscopic studies of biopsy samples, are essential for differentiating the features of various inflammatory stages. Building upon these established diagnostic principles, our study integrates immunohistological analysis with measurements of intramyocardial indices and intracardiac hemodynamics.
Chronic obstructive pulmonary disease is a major cause of morbidity and mortality worldwide, often associated with multiple comorbidities that may complicate its clinical course. These comorbidities can exacerbate respiratory symptoms, impair lung function, alter imaging findings, and significantly affect prognosis.
Diagnosing community-acquired pneumonia in patients with chronic heart failure can be challenging. Oxidative stress and inflammatory response play an important role in the development and diagnosis of community-acquired pneumonia and are also involved in many cardiovascular diseases, including chronic heart failure.
Age-related macular degeneration is a multifactorial, polyetiological condition, affecting individuals over the age of 50, primarily characterized by progressive and irreversible loss of central vision. In the pursuit of a deeper understanding of its etiopathogenesis, risk factors, associated biomarkers, and diagnostic metabolites, the omics approach plays an essential role. The primary objective of this study was to evaluate selected omics biomarkers along with hematological and clinical data and to establish their correlations with macular degeneration.
Detrusor overactivity has been detected in approximately 50% of women with overactive bladder symptoms. According to the NICE guidelines, urodynamic testing is mandatory confirm the diagnosis of detrusor overactivity before performing minimally invasive treatment.
Accurate measurement of the esophageal hiatus is essential during laparoscopic repair of hiatal hernia, especially in patients with gastroesophageal reflux disease. Traditional intraoperative assessments are often subjective and inconsistent. This study proposes a novel, objective method for measuring the hiatal surface area using digital photography and open-source image analysis software.
Severe aortic stenosis and ischemic coronary artery disease are frequently associated in elderly patients, adding complexity to interventional management. Diastolic dysfunction, a marker of myocardial impairment and elevated filling pressures, may influence prognosis after transcatheter aortic valve implantation (TAVI), particularly in the presence of concomitant coronary pathology. The aim of the study was to analyze the interaction between severe aortic valve stenosis, left ventricular diastolic dysfunction, and coronary ischemia in elderly patients with complex cardiovascular disease.
The common carotid artery is the main source of blood supply to the head and neck regions. Its branching patterns are of great interest in terms of both anatomical and clinical significance. Variability of the common carotid artery can influence the planning of vascular, endovascular and oncological interventions in the head and neck regions, to avoid vessel injuries as well as intra-operative and postoperative complications.
The data reported in the specialty literature on the embryogenesis of the facial nerve mainly refer to the initial stages of its development. Nevertheless, the intrauterine development of the facial nerve is a complex and insightful process, characterized by a range of peculiarities. The goal of our study was to highlight the specific developmental features of the facial nerve for a better understanding of its morphology in adults